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phenobarbital will reduce the level or result of flurbiprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unfamiliar.phenobarbital will minimize the extent or impact of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.phenobarbital will decrease the extent or impact of isavucona

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